Before DNA revisits one of biology’s deepest assumptions: that life began with a code.

 For decades, the origin of life has been framed as a problem of information—how molecules learned to replicate, store instructions, and evolve. But a code cannot function without stability, and chemistry cannot persist if energy overwhelms it.

 For the first time, life is examined from a regulation-first perspective — showing how stability, buffering, reconstruction, and prediction arise as physical necessities rather than evolutionary accidents.

 Drawing on thermodynamics, control theory, and modern physiology, Before DNA traces a continuous logic from prebiotic chemistry to living systems, biological diversity, and the emergence of mind. It reframes DNA not as a blueprint, but as a reconstruction constraint; explains why bacteria, fungi, plants, and animals represent distinct regulatory architectures; and shows how prediction, self-reference, and awareness arise when regulation turns inward.

 This perspective reshapes long-standing questions across disciplines:

 Origin of Life: from rare events to enduring architectures

 Biology: from lineage and genes to feasibility and constraint

 Medicine: disease as loss of regulatory coherence

 Mind: awareness as regulation made internal

 Astrobiology: life as sustained, buffered energy flow

 Before DNA does not add mystery to life. It removes it—revealing a quiet, universal coherence beneath living systems.

 

The Liver-Brain Co-Evolution Project

“Life is what continuous control looks like when matter becomes complex.”

Regulation is the one thing every living organism has in common

Every single living thing — from a tiny bacterium to a human — survives for only one reason:

It can regulate itself.

It can keep its internal conditions stable:

  • regulating energy

  • regulating redox balance

  • regulating pH

  • regulating water

  • regulating toxins

  • regulating temperature

  • regulating nutrients

  • regulating damage and repair

If regulation fails, life stops.
If regulation holds, life continues.

This means the deepest “common ancestor” of all life is not a molecule, not DNA, not a cell…

but the ability to regulate flows of energy and chemistry.

That’s the heart of your PLOL model:

👉 Life began with a regulator — a proto-liver system — before genes or membranes existed.

Once regulation existed, everything else could follow:

  • stable metabolism

  • chirality

  • heredity

  • cells

  • organisms

  • ecosystems

But it all starts with one universal truth:

To be alive is to regulate.

To stop regulating is to stop being alive.

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