Before DNA revisits one of biology’s deepest assumptions: that life began with a code.
For decades, the origin of life has been framed as a problem of information—how molecules learned to replicate, store instructions, and evolve. But a code cannot function without stability, and chemistry cannot persist if energy overwhelms it.
For the first time, life is examined from a regulation-first perspective — showing how stability, buffering, reconstruction, and prediction arise as physical necessities rather than evolutionary accidents.
Drawing on thermodynamics, control theory, and modern physiology, Before DNA traces a continuous logic from prebiotic chemistry to living systems, biological diversity, and the emergence of mind. It reframes DNA not as a blueprint, but as a reconstruction constraint; explains why bacteria, fungi, plants, and animals represent distinct regulatory architectures; and shows how prediction, self-reference, and awareness arise when regulation turns inward.
This perspective reshapes long-standing questions across disciplines:
Origin of Life: from rare events to enduring architectures
Biology: from lineage and genes to feasibility and constraint
Medicine: disease as loss of regulatory coherence
Mind: awareness as regulation made internal
Astrobiology: life as sustained, buffered energy flow
Before DNA does not add mystery to life. It removes it—revealing a quiet, universal coherence beneath living systems.
The Liver-Brain Co-Evolution Project
“Life is what continuous control looks like when matter becomes complex.”
Regulation is the one thing every living organism has in common
Every single living thing — from a tiny bacterium to a human — survives for only one reason:
It can regulate itself.
It can keep its internal conditions stable:
regulating energy
regulating redox balance
regulating pH
regulating water
regulating toxins
regulating temperature
regulating nutrients
regulating damage and repair
If regulation fails, life stops.
If regulation holds, life continues.
This means the deepest “common ancestor” of all life is not a molecule, not DNA, not a cell…
but the ability to regulate flows of energy and chemistry.
That’s the heart of your PLOL model:
👉 Life began with a regulator — a proto-liver system — before genes or membranes existed.
Once regulation existed, everything else could follow:
stable metabolism
chirality
heredity
cells
organisms
ecosystems
But it all starts with one universal truth:
To be alive is to regulate.
To stop regulating is to stop being alive.
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